Hebrew University Scientists Create Molecule That Destroys RNA Linked to Cancer Growth

Jerusalem, November 13, 2025 — A research team from the Hebrew University of Jerusalem has announced a breakthrough in the fight against cancer. The scientists have developed a unique molecule capable of identifying and destroying a specific RNA segment associated with tumor cell growth.

The discovery targets a long non-coding RNA known as TERRA, which plays a key role in maintaining the structure of telomeres — the ends of chromosomes that protect a cell’s genetic material. In cancer cells, TERRA often behaves abnormally, helping tumors evade natural “aging” processes and continue dividing indefinitely.

The new molecule, designed by the Israeli team, is based on RIBOTAC technology (Ribonuclease-Targeting Chimera). It recognizes a distinctive structure within TERRA — the so-called G-quadruplex — and recruits the cellular enzyme RNase L, which effectively “cuts” the RNA. This process disrupts one of the key survival mechanisms of cancer cells.

The study, published in the journal Advanced Science, demonstrated in cell models that degrading TERRA significantly slows tumor growth. The researchers emphasize that the work is still at the preclinical stage, but the approach opens the door to a new class of anti-cancer drugs designed to target RNA rather than proteins.

“For the first time, we’ve been able to specifically target RNA molecules that were previously considered ‘undruggable,’” said the study’s lead author, a professor at the Hebrew University of Jerusalem.